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Name of analgesic |
Dosage |
Method
|
Frequency
|
Remark |
Aspirin |
10-100 mg/kg
(up to 400 mg/kg) |
orally |
sid-tid |
Aspirin is a blood thinner
and *must* therefore be avoided in case there are internal bleedings or when surgery
is planned |
Carprofen |
1-2.2 mg/kg
|
orally |
bid |
Effective during 12 to 24 hours |
2-4 mg/kg
|
SC, IV |
sid |
||
Flunixin |
0.3-1.1 mg/kg
|
orally, SC, IM,
IV |
bid, sid |
Effective during 12 to 24 hours Injection should be made
deep into the muscle mass, to avoid irritation. The efficacy of flunixin in rabbits is sometimes questioned |
Flurbiprofen |
1 drop |
topical |
tid, bid |
Only for eyes and in the
nasal cavity |
Ibuprofen |
2-10 mg/kg
|
orally |
sid - tid |
Can cause gastric irritation, or ulceration |
Ketoprofen |
1-3 mg/kg
|
IM |
bid, sid |
Effective during 24 hours Known to interact with
aspirin or |
Indomethacin |
12.5 mg/kg BW |
. |
. |
. |
Medetomidine |
0.1-0.5 mg/kg
|
IM, SC |
. |
Effective during 4 to 6 hours |
0.3-0.5 mg/kg
|
SC |
|||
0.25 mg/kg |
IM |
|||
Meloxicam |
0.3-0.6 mg/kg
up to 1.5 mg/kg if
needed in case of severe pain only |
orally, SC, IM |
sid, bid |
Very palatable for
rabbits Effective
during 12 to 24 hours Concurrent use with another NSAID, corticosteroid,
or nephrotoxic medication must be avoided. If unavoidable, the rabbit should
be monitored closely. Long-term use appears to cause little adverse
effects in rabbits Should not be used in rabbits suffering from liver
or kidney failure |
Paracetamol |
200-500 mg/kg
|
orally |
|
|
Piroxicam |
0.3 mg/kg |
orally |
q 8 |
. |
Buprenorphine |
0.01-0.05 mg/kg
|
SC, IV, IM |
qid, bid |
Respiratory depression
may be observed Effective during 6 to 12 hours Can be used to reverse
the effect of m-opioids, e.g. fentanyl and treat post-surgical pain |
Butorphanol |
0.1-0.5 mg/kg
|
SC, IV, IM |
q 2-4 |
Quick turn-over in
rabbits: 3.16 h. after SC injection, 1.64
h. after IV injection Effective
during 2 hours in rabbits Can be used to reverse
the effect of m-opioids, e.g. fentanyl and treat post-surgical pain |
Hydromorphone |
0.1-0.2
mg/kg
|
IV |
q 4-6 |
Relieves moderate to severe pain |
Fentanyl patches |
12.5 microgram patch for a 3 kg rabbit |
|
|
Can cause drowsiness Patch should be covered to avoid ingestion |
Meperidine (Pethidine) |
5-10 mg/kg
|
SC, IM |
q 2-3 |
Can be used as an
pre-anesthetic |
Morphine |
2-5 mg/kg
|
SC, IM |
q 2-4 |
Effective during
2 to 3 hours |
Nabulpine |
1-2 mg/kg
|
IM, IV |
q 4-5 |
Can be used to reverse
the effect of m-opioids, e.g. fentanyl and treat post-surgical pain |
Oxymorphone |
0.05-0.2 mg/kg
|
SC, IM |
q 8-12 |
Respiratory depression and
bradycardia are reported Can be used as an
pre-anesthetic |
Pentazocine |
5-10 mg/kg
|
SC, IM |
q 5-10 |
Can be used to reverse
the effect of m-opioids, e.g. fentanyl and treat post-surgical pain |
Pethidine |
5 - 10 mg/kg |
SC, IM, IV |
q 2-3 |
|
Tramadol |
5-10mg/kg,
if needed up to 15mg/kg |
orally |
every 8 to 12 hours |
Used to treat moderate or chronic pain in rabbits Use of higher doses (10 mg/kg and higher) have a
very strong effects in rabbits, causing drowsiness and depression of the central
nervous system |
5 mg/kg |
IV, SC |
every 8 hours |
Meaning of the abbreviations, click here
Further information Dana G. Allen, J. K Pringle, Dale A. Smith, Handbook of Veterinary
Drugs. Lippincott – Raven 1998. Elizabeth V. Hillyer and Katherine E. Quesenberry, Ferrets, Rabbits, and Rodents: Clinical
Medicine and Surgery. New York: WB Saunders Co. 1997. Frances Harcourt-Brown, Rabbit Medicine and Surgery.
Butterworth-Heinemann 2001. Kathy Laber-Laird, Paul Flecknell
and M. Michael Swindle, Handbook of Rodent and Rabbit Medicine. Oxford, UK: Pergamon Press 1996. John E. Harkness and Joseph E. Wagner, The Biology and Medicine of
Rabbits and Rodents. New York: Lippincott Williams & Wilkins 1995. Paul Flecknell, BSAVA Manual of Rabbit
Medicine and Surgery. British Small Animal Veterinary Association
2000.Virginia Richardson, Rabbits: Health, Husbandry and Disease, Blackwell
Science Inc 2000. H. Schall, Kaninchen,
In: Krankheiten der Heimtiere (K Gabrisch & P Zwart, eds), Schlütersche
& Co, Hannover (D); pp 1-45, 1998 |
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