Analgesics drugs for use in rabbits

 

 

 

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Name of analgesic

Dosage

Method
Frequency

Remark

 

Aspirin

10 - 100 mg/kg

(up to 400 mg/kg)

PO

sid-tid

Aspirin is a blood thinner and *must* therefore be avoided in case there are internal bleedings or when
surgery is planned

 

Carprofen

1.5 mg/kg

PO

sid

.

1 - 2 mg/kg

SC, IV

sid

Flunixin

1.1 mg/kg

SC, IM

bid, sid

Injection should be made deep into the muscle mass, to avoid irritation.

The efficacy of flunixin in rabbits is sometimes questioned

Ibuprofen

2 - 10 mg/kg

PO

sid - tid

Can cause gastric irritation, or ulceration

Ketoprofen

3 mg/kg

IM

bid, sid

Known to interact with aspirin or
diuretic agents

Indomethacin

12.5 mg/kg BW

.

.

.

Medetomidine

0.1-0.5 mg/kg

IM, SC

.

.

0.3-0.5 mg/kg

SC

0.25 mg/kg

IM

Meloxicam

0.1 - 0.2 mg/kg

up to 1.5 mg/kg if needed

PO, SC

sid ?

Action lasts between 12-24 h.

Very palatable for rabbits

Concurrent use with another NSAID, corticosteroid, or nephrotoxic medication must be avoided. If unavoidable, the rabbit should be monitored closely.

Long-term use appears to cause little adverse effects in rabbits

Should not be used in rabbits suffering from liver or kidney failure

Piroxicam

0.3 mg/kg

PO

qod

.

 

Buprenorphine

0.01 - 0.05 mg/kg

SC, IV

qid, bid

Respiratory depression may be observed

Can be used to reverse the effect of m-opioids, e.g. fentanyl and treat post-surgical pain

Butorphanol

0.1 - 0.5 mg/kg

SC, IV

q 2-4

Quick turn-over in rabbits: 3.16 h. after SC injection, 1.64  h. after IV injection

Can be used to reverse the effect of m-opioids, e.g. fentanyl and treat post-surgical pain

Hydromorphone

0.1 - 0.2 mg/kg

IV

q 4-6

Relieves moderate to severe pain

Meperidine (Pethidine)

5 - 10  mg/kg

SC, IM

q 2-3

Can be used as an pre-anesthetic

Morphine

5 mg/kg

SC, IM

q 2-4

.

2-5 mg/kg

SC, IM

q 2-4

Nalbuphine

1 – 2 mg/kg

SC, IM

q 4

Can be used to reverse the effect of m-opioids, e.g. fentanyl and treat post-surgical pain

Oxymorphone

0.05 – 0.2 mg/kg

SC, IM

q 8-12

Respiratory depression and bradycardia are reported

Can be used as an pre-anesthetic

Pentazocine

5 – 10 mg/kg

SC, IM

q 5-10

Can be used to reverse the effect of m-opioids, e.g. fentanyl and treat post-surgical pain

Tramadol hydrochloride

2 - 4 mg/kg

PO

bid

Used to treat moderate to severe pain in rabbits

Use of higher doses (e.g. 10 mg/kg) has too strong effects in rabbits

 

Meaning of the abbreviations, click here.

 

 

 

Further information

 

Dana G. Allen, J. K Pringle, Dale A. Smith, Handbook of Veterinary Drugs. Lippincott – Raven 1998.

Elizabeth V. Hillyer and Katherine E. Quesenberry, Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. New York: WB Saunders Co. 1997.

Frances Harcourt-Brown, Rabbit Medicine and Surgery. Butterworth-Heinemann 2001.

Kathy Laber-Laird, Paul Flecknell and M. Michael Swindle, Handbook of Rodent and Rabbit Medicine. Oxford, UK: Pergamon Press 1996.

John E. Harkness and Joseph E. Wagner, The Biology and Medicine of Rabbits and Rodents. New York: Lippincott Williams & Wilkins 1995.

Paul Flecknell, BSAVA Manual of Rabbit Medicine and Surgery. British Small Animal Veterinary Association 2000.Virginia Richardson, Rabbits: Health, Husbandry and Disease, Blackwell Science Inc 2000.

H. Schall, Kaninchen, In: Krankheiten der Heimtiere (K Gabrisch & P Zwart, eds), Schlütersche & Co, Hannover (D); pp 1-45, 1998

 

 

 

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