Fleas and Rabbits



Esther van Praag Ph.D.



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Fleas can plague rabbits as well as humans. Wild rabbits are mainly infested by the rabbit flea Spilopsyllus cuniculi. The lifecycle of Spilopsyllus cuniculi is synchronized to the lifecycle of the wild rabbit in such a way that eggs are laid after the birth of newborn rabbits. The female flea deposits her eggs inside the nest, where the necessary humidity is present for their development. The survival of the hatched larvae can only happen when humidity is higher than 50%. They feed on the feces of the adult fleas, which are rich in blood sucked from the host.

The flea population infesting a rabbit is composed of eggs (50%), larvae (35%), pupas (10%) and only 5% adults. The development of the fleas is quick and will infest new rabbits.

The length of the lifecycle depends on the humidity of the air and the temperature. In general it lasts between 12 and 14 days, but can take as long as 6 months. Inside a house or an apartment, the complete life cycle takes between 9 days and 4 weeks’ time.



Farmers Bulletin 1568 – bureau of Animal Industry; M.W. Meek, Diseases and Parasites of Rabbits and their control

Spilopsyllus cuniculi, the rabbit flea

Farmers Bulletin 1568 – bureau of Animal Industry; M.W. Meek, Diseases and Parasites of Rabbits and their control

Echinnophaga gallinacea, the chicken flea that can also infest rabbits

Various species of fleas have been found on rabbits. They include Pulex irritans, Cediopsylla simples, Odontopsyllus multispinosus, Echinnophaga gallinacea, or Echidnophasis mymecobil. Domestic rabbits are commonly infested by the cat or dog fleas: Ctenocephalides felis or Ctenocephalides canis, respectively.

The presence of Ctenocephalides felis can cause serious irritation in animals and man. It may be couple with an allergic reaction against the anti-coagulase enzyme present in the injected saliva of the flea. This enzyme is necessary to keep the fleabite open to allow a continuous flow of fresh blood to the flea.





Cat flea, Ctenocephalides felis


Dog flea, Ctenocephalides canis


Fleas can be carrier of contagious diseases, e.g., myxomatosis, or tularemia, and of tapeworm species specific to the rabbit. The rabbit flea Spilopsyllus cuniculi can transmit dangerous diseases or parasites affecting the wild rabbit population to pet rabbits, such as the viral agent causing myxomatosis or the rabbit protozoan parasite Trypanosoma nabiasi.

Clinical signs and diagnosis

The presence of fleas is typically subclinical and seasonal, with a peak observed at the end of the summer. Infestation is characterized by the presence of the feces of the fleas and their eggs in the fur, or on a flea comb.



                                                                Jen Smuck                                                                    

Presence of flea dirt in the fur and a red spot on the skin of a rabbit is indicative of the presence of fleas.


Flea comb

The presence of fleas is frequently observed at the periphery of the ears, between them, on the eyelids or the nose of the rabbit. Other locations on the body should nevertheless not be ruled out. In rare cases, a strong allergic reaction against the saliva injected by the flea takes place. If such a reaction is observed, it is recommended to examine the rabbit for further skin disease.

The presence of Spilopsyllus cuniculi often leads to pruritic skin and the appearance of crusts. 

Fleabites can be accompanied by secondary bacterial infections. Systemic antibiotics are indicated. A bacterial culture, followed by a sensitivity test, will help determine the best antibiotic option.


It is important to treat both the rabbit infested by fleas, other pet animals in the household, and the environment.

Fleas are eliminated by sprays, powder products or topical products:

    pyrethrin based products.

    selamectin: Revolution® (US) or Stronghold® (Europe) - Pfizer, 18 mg/kg. A single topical (local) dose should be sufficient; if not, repeat in 30 days.

    imidacloprid: Advantage® - Bayer, one single application is generally sufficient to remove the fleas. If this is not the case, the treatment can be repeated after 30 days. The vapors of this product can lead to irritation of the eyes; it is thus recommended to aerate the room where the rabbit lives in.

    lufenuron: Program® - Novartis, 10 mg/kg. One sole treatment should be sufficient. If not, the treatment can be repeated after 30 days.

Impregnated anti-flea collars should never be used in rabbits. They lead to severe irritation and burning of the skin. There are reported cases, where the rabbit attempted to remove its collar, and died as a result of jamming its jaw in the collar.

Treatment of the environment is important (boric acid such as Fleabusters®; Vet-Kem Acclaim Plus® - Sanofi; Staykil® - Novartis; Indorex® - Virbac; acaricide spray). When treating a carpet, vacuum first in order to further penetration of the spray or powder. Shampooing and steam cleaning are not ideal; their residual humidity can increase the mite problem. During treatment of the environment, rabbits should be kept in another part of the home to avoid the danger of contact with the products.


For detailed information on flea infestation in rabbits,

see: “Skin Diseases of Rabbits”, by E. van Praag, A. Maurer and T. Saarony

408 pages, 2010.

Further Readings

Amin OM. Comb variations in the rabbit flea, Cediopsylla simplex (Baker). J Med Entomol. 1974;11:227-230.

Farlow JE, Burns EC, Newsom JD. Seasonal distribution of some arthropod parasites of rabbits in Louisiana. J Med Entomol. 1969;6:172-174. 

Graves GN, Bennett WC, Wheeler JR, Miller BE, Forcum DL. Sylvatic plague studies in southeast New Mexico. II. Relationships of the desert cottontail and its fleas. J Med Entomol. 1978;14:511-522. 

Gurycova D. First isolation of Francisella tularensis subsp. tularensis in Europe. Eur J Epidemiol. 1998; 14:797-802. 

Hutchinson MJ, Jacobs DE, Bell GD, Mencke N. Evaluation of imidacloprid for the treatment and prevention of cat flea (Ctenocephalides felis felis) infestations on rabbits. Vet Rec. 2001; 148(22):695-696. 

Launay H. On the phenology of the flea Xenopsylla cunicularis Smit, 1957 (Siphonaptera, Pulicidae) parasite of the European rabbit. Ann Parasitol Hum Comp. 1982;57(2):145-163. 

Mead-Briggs AR, Vaughn JA, Rennison BD. Seasonal variation in numbers of the rabbit flea on the wild rabbit. Parasitology. 1975;70(1):103-118.

Merchant JC, Kerr PJ, Simms NG, Robinson AJ. Monitoring the spread of myxoma virus in rabbit Oryctolagus cuniculus populations on the southern tablelands of New South Wales, Australia. I. Natural occurrence of myxomatosis. Epidemiol Infect. 2003; 130(1):113-121.

Osacar-Jimenez JJ, Lucientes-Curdi J, Calvete-Margolle C. Abiotic factors influencing the ecology of wild rabbit fleas in north-eastern Spain. Med Vet Entomol. 2001;15(2):157-66.

Osacar JJ, Lucientes J, Calvete C, Peribanez MA, Gracia MJ, Castillo JA. Seasonal abundance of fleas (Siphonaptera: Pulicidae, Ceratophyllidae) on wild rabbits in a semiarid area of northeastern Spain. J Med Entomol. 2001; 38(3):405-410.

Pfaffenberger GS, Valencia VB. Ectoparasites of sympatric cottontails (Sylvilagus audubonii Nelson) and jack rabbits (Lepus californicus Mearns) from the high plains of eastern New Mexico. J Parasitol. 1988; 74(5):842-6. 

Pinter L. Leporacarus gibbus and Spilopsyllus cuniculi infestation in a pet rabbit. J Small Anim Pract. 1999; 40(5):220-221. 

Rothschild M. Myxomatosis and the rabbit flea. Nature. 1965; 207(2):1162-1163. 

Shepherd RC. Myxomatosis: the occurrence of Spilopsyllus cuniculi (Dale) larvae on dead rabbit kittens. J Hyg (Lond). 1978; 80(3):427-9.

Timm KI. Pruritus in rabbits, rodents, and ferrets. Vet Clin North Am Small Anim Pract. 1988; 18(5):1077-91. 

Vashchenok VS, Shuliat'ev AA. Spilopsyllus cuniculi fleas--parasites of the wild rabbit on the territory of the USSR. Parazitologiia. 1990; 24(2):148-51.





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